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Functional Brain Changes in Presymptomatic Hunington's Disease Ann Neurol 55:879-883, Reading,S.A.,et al, 2004 See this aricle in Pubmed Article Abstract Evidence suggests early structural brain changes in individuals with the HuntingtonÆs disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging ôinterferenceö protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulated cortex (BA 24, 32) compared with matched controls.

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(click to filter results - removes previous filter) asymptomatic cingulate gyrus Huntington's chorea Huntington's chorea,presymptomatic detection of MRI MRI,abnormal MRI,functional neurologic disease,diagnoses of preclinical

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